BDBM614293 US20230270730, Compound A-45

SMILES CCCNS(=O)(=O)Nc1nccc(Cc2cc(C(=O)NOCCO)c(Nc3ccc(I)cc3F)c(F)c2F)c1F

InChI Key InChIKey=OHRLRWVLPBHNJE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 614293   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614293(US20230270730, Compound A-45)
Affinity DataIC50:  6nMAssay Description:The test compound, BRAF (Eurofins Genomics KK.) and MEK1 (Thermo Fisher Scientific Inc.) were mixed in ATP-containing buffer and reacted for 90 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614293(US20230270730, Compound A-45)
Affinity DataIC50:  2nMAssay Description:The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent