BDBM617000 US20230279025, Example 60
SMILES O[N+]12CCCC1(COc1nc(N3CC4CCC(C3)N4)c3cnc(c(F)c3n1)-c1cccc3cccc(Cl)c13)CCC2
InChI Key InChIKey=UAIGJAAMJLAQRK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 617000
Affinity DataIC50: 1.66E+3nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+6nMAssay Description:Briefly, 1L of 1.05X HBS-Mg buffer (262.5 mM Bioultra Hepes, pH 7.5, 157.5 mM NaCl, 105 mM MgCl2, 0.525 mM TCEP, 0.0305% Brij-35) was prepared and fi...More data for this Ligand-Target Pair