BDBM621046 (6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimidine-2-yl)amino)pyridine-3-yl)(piperazine-1-yl)ketone hydrochloride::US20230303553, Example 17

SMILES Cc1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F

InChI Key InChIKey=UYRUSUBNRZEGRJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621046   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621046((6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimi...)
Affinity DataIC50:  27nMAssay Description:The DYRK2 kinase inhibitory activity of the compounds of the invention were measured. The method was briefly described as follows (for specific metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621046((6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimi...)
Affinity DataIC50:  93nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent