BDBM621739 BDBM621797::US11802122, Example 3A::US20230312522, Compound 3::US20230312522, Compound 5

SMILES FC(F)c1nc(ccc1Cl)C(NC(=O)[C@@H]1CNC(=O)N1)c1cnc(c(Cl)c1)C(F)(F)F

InChI Key InChIKey=HTNVQQVGOLYPHY-VUWPPUDQSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 621739   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621739(BDBM621797 | US11802122, Example 3A | US2023031252...)
Affinity DataIC50:  9.70nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for NaV1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Sage Therapeutics

US Patent
LigandPNGBDBM621739(BDBM621797 | US11802122, Example 3A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Sage Therapeutics

US Patent
LigandPNGBDBM621739(BDBM621797 | US11802122, Example 3A | US2023031252...)
Affinity DataIC50: >1.00E+3nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621739(BDBM621797 | US11802122, Example 3A | US2023031252...)
Affinity DataIC50:  2.70nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent