BDBM625347 US20230322769, Compound 55

SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1

InChI Key InChIKey=GVIULWWJXLMODX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 625347   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625347(US20230322769, Compound 55)
Affinity DataIC50:  12.3nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625347(US20230322769, Compound 55)
Affinity DataIC50:  39.7nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625347(US20230322769, Compound 55)
Affinity DataIC50:  223nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625347(US20230322769, Compound 55)
Affinity DataIC50:  7.45nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625347(US20230322769, Compound 55)
Affinity DataIC50:  15.3nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent