BDBM639784 1-[6,7-Dichloro-9-(3-hydroxypropylamino)-10-(1H-pyrazol-4-yl)-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl]ethanone::US20230391786, Example 253

SMILES CC(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(NCCCO)cc(Cl)c(Cl)c21

InChI Key InChIKey=ZBMAOUTZTDFNTA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639784   

TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639784(1-[6,7-Dichloro-9-(3-hydroxypropylamino)-10-(1H-py...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent