BDBM639879 3,4-Dichloro-1-(3-hydroxypropoxy)-10-(1H-pyrazol-4-yl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-7-ol::US20230391786, Example 348

SMILES OCCCOc1cc(Cl)c(Cl)c2n3CC(O)CCc3c(-c3cn[nH]c3)c12

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639879   

TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639879(3,4-Dichloro-1-(3-hydroxypropoxy)-10-(1H-pyrazol-4...)
Affinity DataIC50:  6.95nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent