BDBM640380 Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide ::US11840535, Example 22

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cn([C@H]4CC[C@H](O)CC4)c4ncnc(N)c34)cc2C(F)(F)F)CC1

InChI Key InChIKey=XSOXPLMEUJTPMW-OGESRWMOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 640380   

TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM640380(Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyc...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM640380(Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyc...)
Affinity DataIC50: <5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent