BDBM644623 US11866450, Compound 35::US11866450, Compound 36

SMILES CC1CCC2CN(c3nc(ccc3C(=O)NS(=O)(=O)c3cccc(N1)n3)-n1ccc(OCCC3(CC3)C(F)(F)F)n1)C(C)(C)C2

InChI Key InChIKey=OTVLYYYADBXMPK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644623   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM644623(US11866450, Compound 35 | US11866450, Compound 36)
Affinity DataEC50: <1.00E+3nMAssay Description:Bath 1 Buffer consisted of 1 mM MgCl2, 160 mM NaCl, 4.5 mM KCl, 10 mM HEPES, 10 mM Glucose, 2 mM CaCl2).Chloride Free Buffer consisted of 1 mM Magnes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM644623(US11866450, Compound 35 | US11866450, Compound 36)
Affinity DataEC50: <1.00E+3nMAssay Description:Bath 1 Buffer consisted of 1 mM MgCl2, 160 mM NaCl, 4.5 mM KCl, 10 mM HEPES, 10 mM Glucose, 2 mM CaCl2).Chloride Free Buffer consisted of 1 mM Magnes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent