BDBM64564 US9428505, Compound 8

SMILES Cc1cc(cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(NC2=O)c1ccc(OC(F)(F)F)cc1)N1C(=O)NC(=O)C11CCCC1

InChI Key InChIKey=XRQFZVXCVAFCOM-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 64564   

TargetParathyroid hormone [32-65](Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM64564(US9428505, Compound 8)
Affinity DataEC50:  3.60E+3nMpH: 7.4Assay Description:HKRK-B7 or LLC-PK1 cells were seeded into a 96-well plate at 1×105 cells/well and incubated overnight. On the following day, 50 μl of cAMP assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM64564(US9428505, Compound 8)
Affinity DataEC50:  3.60E+3nMAssay Description:Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Rattus norvegicus (Rat))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM64564(US9428505, Compound 8)
Affinity DataEC50:  1.90E+3nMpH: 7.4Assay Description:Instead of HKRK-B7 cells, LLC-PK46_RATO_PTH1R cells overexpressing rat PTH1R, which were established at Chugai Pharmaceutical, were used to take meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent