BDBM646010 (2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxyphenyl)-5,6,6a,7,9,10-hexahydro-8H- pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazin-8- yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)- 1-(4-(4-methylthiazol-5- yl)phenyl)ethyl)pyrrolidine-2-carboxamide (Diastereomer 1 - *)::US20240018158, Example 1a::US20240018158, Example 1b

SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN2C(CNc3nnc(cc23)-c2ccccc2O)C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

InChI Key InChIKey=VPQLVRUINVTYPJ-URXOJDOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 646010   

TargetProbable global transcription activator SNF2L2(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM646010((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Affinity DataIC50:  550nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription activator BRG1(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM646010((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable global transcription activator SNF2L2(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM646010((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent