BDBM646442 US11878973, Example 123::US11878973, Example 133::US11878973, Example 42::US11878973, Example 43

SMILES CCc1c(N2CCN(CC2)C(=O)c2ncnc(C)c2O)c(=O)n2nc(nc2n1CC(=O)Nc1ccc(cc1Cl)C(F)(F)F)C1=CCOCC1

InChI Key InChIKey=XKYVECRUZPCRQR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 646442   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646442(US11878973, Example 123 | US11878973, Example 133 ...)
Affinity DataIC50:  100nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646442(US11878973, Example 123 | US11878973, Example 133 ...)
Affinity DataIC50:  120nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646442(US11878973, Example 123 | US11878973, Example 133 ...)
Affinity DataIC50:  100nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646442(US11878973, Example 123 | US11878973, Example 133 ...)
Affinity DataIC50:  70nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent