BDBM647654 US20240025908, Example 22
SMILES CCOc1ncc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NOCCN3)c2n1
InChI Key InChIKey=SXRLSRMWBAVNFG-LLVKDONJSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 647654
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Homo sapiens (Human))
Tyk Medicines
US Patent
Tyk Medicines
US Patent
Affinity DataIC50: 2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Affinity DataIC50: 27.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Tyk Medicines
US Patent
Tyk Medicines
US Patent
Affinity DataIC50: 2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Affinity DataIC50: 2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair