BDBM647657 US20240025908, Example 25

SMILES C[C@@H](Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1)c1cc(F)cnc1OC(F)(F)F

InChI Key InChIKey=LTPMGUPHSVPNRT-SECBINFHSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 647657   

TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Tyk Medicines

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Homo sapiens (Human))
Tyk Medicines

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor [G1202R](Homo sapiens (Human))
Tyk Medicines

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50:  27.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Tyk Medicines

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tyk Medicines

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tyk Medicines

US Patent
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent