BDBM647850 US20240025919, Compound 80

SMILES CCc1cccc2cc(O)cc(-c3nc4O[C@@H](C)[C@@H]5[C@@H]6CC[C@H](CN5c5nc(OC[C@@]78CCCN7CC(=C)C8)nc(c3F)c45)N6)c12

InChI Key InChIKey=OCXITLQCVGLINJ-KUXSHPFJSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647850   

TargetGTPase KRas [G12D](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM647850(US20240025919, Compound 80)
Affinity DataIC50:  0.0680nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM647850(US20240025919, Compound 80)
Affinity DataIC50:  3.39nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS WT. In this assay, the SOS1-promote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent