BDBM657663 N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-dimethoxy-2-methylquinazolin-4-amine::US20240083857, Example 342

SMILES COc4cc3nc(C)nc(N[C@H](C)c2cccc(c1cn[nH]c1)c2)c3cc4OC

InChI Key InChIKey=OYHDNGCDWWAYLR-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 657663   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 140nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 190nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 470nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-L...More data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 480nMAssay Description:Inhibition of SOS1 in human K562 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 500nMAssay Description:Inhibition of SOS1 in human MOLM-13 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 740nMAssay Description:Inhibition of SOS1 in human HeLa cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-LIS...More data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetGuanine nucleotide exchange factor DBS(Homo sapiens)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human DBS assessed as reduction in CDC42 activation preincubated for 1 min with CDC42 followed by DBS addition measured after 20 mins i...More data for this Ligand-Target Pair

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TargetSon of sevenless homolog 2(Homo sapiens)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS2 catalytic domain (564 to 1043 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair

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TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human EGFR using biotin-aminohexyl-AEEEEYFELVAKKK as substrate preincubated for 15 mins followed by substrate/ATP addition measured aft...More data for this Ligand-Target Pair

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TargetGTPase KRas(Human)
Bayer AG

Curated by ChEMBL

LigandBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli assessed as reduction in int...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
10/13/2025
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