BDBM6763 28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-3,5-dione::SB-218078

SMILES O=C1NC(=O)c2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13

InChI Key InChIKey=OTPNDVKVEAIXTI-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6763   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6763(28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0...)
Affinity DataIC50:  540nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM6763(28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Chk1 mediated phosphorylation of cdc25CChecked by AuthorMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM6763(28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0...)
Affinity DataIC50:  250nMAssay Description:Inhibition of p34cdc2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6763(28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0...)
Affinity DataIC50:  680nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed