BDBM7463 4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine::Pyrazolopyridazine 1a::Pyrazolopyridazine deriv. 1a::pyrazolopyridazine deriv. 1

SMILES Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12

InChI Key InChIKey=NPHKXSDZIKFIRU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7463   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Universidad San Pablo Ceu

LigandPNGBDBM7463(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Affinity DataIC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7463(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Affinity DataIC50:  250nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM7463(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Universidad San Pablo Ceu

LigandPNGBDBM7463(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory concentration against protein tyrosine kinase LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universidad San Pablo Ceu

LigandPNGBDBM7463(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory concentration against KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Central University

Curated by ChEMBL
LigandPNGBDBM7463(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine |...)
Affinity DataIC50:  250nMAssay Description:Inhibition of glycogen synthase kinase-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed