BDBM76305 5-chloranylquinolin-8-ol::5-chloro-8-quinolinol::5-chloroquinolin-8-ol::MLS002695956::SMR000274338::US12377086, Compound 46::cid_2817

SMILES c1cc2c(ccc(c2nc1)O)Cl

InChI Key InChIKey=CTQMJYWDVABFRZ-UHFFFAOYSA-N

Data  2 KI  14 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 76305   

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 3.57E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 5.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 4.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Freie University Berlin

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of C-terminal 6His-tagged full length NDM-1 (unknown origin) expressed in Escherichia coli BL21-DE3 using nitrocefin as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Institut De Recherches Cliniques De Montreal (IRCM)

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 6.47E+3nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HIV-1 integrase 3'-processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of human methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBotulinum neurotoxin type A(Clostridium botulinum)
U.S. Army Medical Research Institute of Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of protease activity of recombinant full length Clostridium botulinum Hall BoNT/A light chain using SNAP-25 peptide (187 to 203 residues) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2019
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 1(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetC-C chemokine receptor type 6(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 6.66E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetBeta-galactosidase(Escherichia coli)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 6.66E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetVacuolar aminopeptidase 1(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataEC50:  2.08E+5nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetMethionine aminopeptidase 1(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of human methionine aminopeptidase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataKi:  960nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataKi:  1.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent