BDBM7886 1-PIM::1-phenyl-1H-imidazole::1-phenylimidazole::CHEMBL275066::US9138393, 1-Phenyl- imidazole::US9144538, 1-Phenylimidazole

SMILES c1cn(cn1)-c1ccccc1

InChI Key InChIKey=SEULWJSKCVACTH-UHFFFAOYSA-N

Data  2 KI  5 IC50  2 Kd  2 ITC

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 7886   

TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM7886(1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole ...)
Affinity DataKd:  2.90E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM7886(1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole ...)
Affinity DataKd: >1.00E+7nMAssay Description:Dissociation constant when binding to FK506 binding protein (FKBP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 7886   

HostPNGBDBM4((1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23...)
Nist

GuestPNGBDBM7886(1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole ...)
ITC DataΔG°: -2.15kcal/mole −TΔS°: 2.63kcal/mole ΔH°: -4.78kcal/mole logk: 37.2
pH: 10.0 T: 24.85°C 
In DepthDetails
HostPNGBDBM11(beta-cyclodextrin | betadex)
Nist

GuestPNGBDBM7886(1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole ...)
ITC DataΔG°: -1.91kcal/mole −TΔS°: 7.40kcal/mole ΔH°: -9.31kcal/mole logk: 25
pH: 10.0 T: 24.85°C 
In DepthDetails