BindingDB BDBM81368 PIK90

BDBM81368 PIK90

SMILES COc1ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc2c1OC

InChI Key InChIKey=ZJAVHOMVDCMAMF-UHFFFAOYSA-N

Data 17 IC50

Found 4 hits for monomerid = 81368

IC50: 58nMAssay Description:Inhibition of PI3Kdelta in presence of 10 uM ATPMore data for this Ligand-Target Pair

IC50: 11nMAssay Description:Inhibition of PI3Kalpha in presence of 10 uM ATPMore data for this Ligand-Target Pair

IC50: 350nMAssay Description:Inhibition of PI3Kbeta in presence of 10 uM ATPMore data for this Ligand-Target Pair

IC50: 18nMAssay Description:Inhibition of PI3Kgamma in presence of 10 uM ATPMore data for this Ligand-Target Pair

Targets 9▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- DNA-dependent protein kinase catalytic subunit 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 2
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
Publications 4▿
- J Med Chem 60: 47-65 (2017) 5
- Chem Biol 17: 123-34 (2010) 4
- J Med Chem 55: 8559-81 (2012) 4
- ACS Med Chem Lett 6: 3-6 (2015) 4
Institutions 4▿
- Curtin University 5
- Amgen 4
- University of California San Francisco 4
- Monash University (Parkville Campus) 4
Affinity: 11 to 8.3E+2 nM▿
- IC50 17
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1