BDBM8246 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6-c

SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)cc1Cl

InChI Key InChIKey=YYGKSMKAYKZSBC-UHFFFAOYSA-N

Data  6 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 8246   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  94nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  94nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataKd:  110nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))TBA
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human recombinant BRDTMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  94nMAssay Description:Inhibition of recombinant human GSKalphaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human recombinant full-length GSK3beta expressed in Escherichia coli incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant full-length GSK3alpha expressed in Escherichia coli incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataKd:  2.21E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails PubMed