BDBM8357 6-aryl-pyrazolo[3,4-b]pyridine analogue 21::CHEMBL407981::N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-(4-ethylpiperazin-1-yl)butanamide::pyrazolo[3,4-b]pyridine analogue 9

SMILES CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(c(Br)cc23)-c2ccc(O)cc2)CC1

InChI Key InChIKey=JIQRMBNAYWCUEG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 8357   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  60nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed