BDBM86633 JNK-IN-8

SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1

InChI Key InChIKey=GJFCSAPFHAXMSF-UXBLZVDNSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 86633   

TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  4.67nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  19nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  0.980nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  1nMAssay Description:Inhibition of JNK3 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  486nMAssay Description:Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  338nMAssay Description:Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  19nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  1nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  1nMAssay Description:Inhibition of JNK3 (unknown origin) after 1 hr by FRET-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50:  18.7nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed