BDBM8961 1,2,3,4-tetrahydro-9-acridinamine::1,2,3,4-tetrahydroacridin-9-amine::9-THA::9-amino-1,2,3,4-tetrahydroacridine (THA)::CHEMBL1337960::CHEMBL95::Cognex::Tacrine::Tracine::US8999994, Tacrine::cid_1935::tacrine.HCl
SMILES Nc1c2CCCCc2nc2ccccc12
InChI Key InChIKey=YLJREFDVOIBQDA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 264 hits for monomerid = 8961
Affinity DataKi: 7nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of Equine ButyrylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
Affinity DataKi: 7nM ΔG°: -11.1kcal/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
Affinity DataKi: 8.70nMAssay Description:Inhibition of human BChE assessed as acetylthiocholine hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.70nMAssay Description:Inhibition of human recombinant BChE using acetylthiocholine as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Competitive inhibition of equine serum BuChE assessed as enzyme-inhibitor complex using p-nitrophenyl butyrate as substrate by Lineweaver-Burk plot a...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of horse serum BChE preincubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of horse serum BChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 45.8nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 43.9nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of BuChE activity was determined by the spectroscopic method of Ellman using butyrylthiocholine iodide as substrate, in 96-well microtiter...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards BuChE was determined following the method of Ellman using BuChE from human serum and butyrylthiochol...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:In vitro Butyrylcholinesterase inhibitory activity of the compound to determine its ability to reverse the cholinergic deficit characteristic of ADMore data for this Ligand-Target Pair
Affinity DataIC50: 363nMAssay Description:Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of BuChE in equine serum using butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge me...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of BChE in horse serum using butyrylthiocholine iodide as substrate after 120 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human plasma.More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine iodide as substrate preincubated for 35 mins followed by enzyme addition measured after 3 min...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of horse serum BuChE using butyrylthiocholine as substrate by UV spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibitory activity against Butyrylcholinesterase (BChE) in human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human BChE by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human plasmatic BChE after 5 mins by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of horse serum BChE by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of equine serum BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of equine serum BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human BuChE pre-incubated for 5 mins before butylthiocholine substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against Butyrylcholinesterase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of human recombinant serum BuchE using butyrylthiocholine iodide as substrate by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 20 mins before butylthicoline iodide substrate addition by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.13E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of BuChE in horse serum pre-incubated for 5 mins before addition of butyrylthiocholine iodide substrate by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of equine serum BuChE pre-incubated for 3 mins before butyrylthiocholine substrate addition by Ellman's reagent based spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of horse serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 se...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of equine serum BuChE after 5 mins by Ellman's methodMore data for this Ligand-Target Pair