BDBM8963 CHEMBL32823::Homodimeric Tacrine Analog 3b::N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-1,2,3,4-tetrahydroacridin-9-amine::Tacrine Dimer 3b::Tacrine-Based Inhibitor 2f::tacrine homobivalent compound 3a
SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
InChI Key InChIKey=ITZOKHKOFJOBFS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 8963
Affinity DataKi: 1.30nM ΔG°: -12.1kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of fetal bovine serum AChEMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of fetal Bovine serum AChEMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nM ΔG°: -12.1kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat brain AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human serum recombinant AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Waterloo
Curated by ChEMBL
University Of Waterloo
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of electric eel AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human AChE incubated with compounf for 5 mins before addition of substrate acetylthiocholine iodide by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory potency against acetylcholinesterase (AChE) of rat cortex homogenate with ethopropazine as BChE inhibitorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of AChE in rat brain cortex using acetylthiocholine iodide as substrate incubated for 8 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibitory concentration against human acetylcholinesteraseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Waterloo
Curated by ChEMBL
University Of Waterloo
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of Wistar rat brain AChE using acetylthiochloline iodide as substrate after 30 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of AChE in Wistar rat brain cortex using acetylthiocholine iodide as substrate by Ellman's colorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 8 mins in presence of BuChE inhibitor ethopropazine by Ellma...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of AChE in Swiss Webster mouse cerebral homogenate using acetylthiocholine iodide as substrate preincubated for 10 mins followed substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by susbtrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair