BDBM9065 Donepezil-tacrine hybrid 10::N-[6-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexyl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide::N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl}-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetamide

SMILES Clc1ccc2c(NCCCCCCNC(=O)CN3C(=O)c4ccccc4C3=O)c3CCCCc3nc2c1

InChI Key InChIKey=JFPMDULIXYETHU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9065   

TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9065(Donepezil-tacrine hybrid 10 | N-[6-(6-Chloro-1,2,3...)
Affinity DataIC50:  220nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9065(Donepezil-tacrine hybrid 10 | N-[6-(6-Chloro-1,2,3...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed