BDBM9070 2-[6-(Acridin-9-ylamino)-hexyl]-isoindole-1,3-dione::2-[6-(acridin-9-ylamino)hexyl]-2,3-dihydro-1H-isoindole-1,3-dione::Donepezil-tacrine hybrid 19

SMILES O=C1N(CCCCCCNc2c3ccccc3nc3ccccc23)C(=O)c2ccccc12

InChI Key InChIKey=ZULDSVIFWWBRHT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9070   

TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9070(2-[6-(Acridin-9-ylamino)-hexyl]-isoindole-1,3-dion...)
Affinity DataIC50:  7.80nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9070(2-[6-(Acridin-9-ylamino)-hexyl]-isoindole-1,3-dion...)
Affinity DataIC50:  870nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed