BDBM9196 2-{4-[(2R)-2-[(2S)-3-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-2-hydroxypropyl]-2-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}ethyl]phenoxy}ethyl morpholine-4-carboxylate::pyrrolidinone based inhibitor 1n

SMILES O[C@@H](C[C@@H](Cc1ccc(OCCOC(=O)N2CCOCC2)cc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)CN1[C@@H](Cc2ccccc2)C[C@H](Cc2ccccc2)C1=O

InChI Key InChIKey=FKLCRUVOWWCXRT-HYESOODXSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 9196   

TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM9196(2-{4-[(2R)-2-[(2S)-3-[(3S,5R)-3,5-dibenzyl-2-oxopy...)
Affinity DataKi:  0.0500nM ΔG°:  -14.0kcal/mole IC50:  240nMpH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed