Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with Target = '3-oxoacyl-[acyl-carrier-protein] synthase 1'
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93049BDBM93049(TLM analog, 6)
Affinity DataKi:  460nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93048BDBM93048(TLM analog, 5)
Affinity DataKi:  900nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 50241313BDBM50241313((R)-(+)-Thiolactomycin | (5R)-4-hydroxy-3,5-dimeth...)
Affinity DataKi:  1.90E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401027BDBM50401027(CHEMBL2204380)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv Fab1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93046BDBM93046(TLM analog, 3)
Affinity DataKi:  7.10E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93054BDBM93054(TLM analog, 11)
Affinity DataKi:  8.00E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93048BDBM93048(TLM analog, 5)
Affinity DataKi:  8.20E+3nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93059BDBM93059(TLM analog, 16)
Affinity DataKd:  1.08E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241313BDBM50241313((R)-(+)-Thiolactomycin | (5R)-4-hydroxy-3,5-dimeth...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93049BDBM93049(TLM analog, 6)
Affinity DataKi:  1.21E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93059BDBM93059(TLM analog, 16)
Affinity DataKi:  1.38E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93047BDBM93047(TLM analog, 4)
Affinity DataKi:  1.60E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138281BDBM50138281(4-Hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93049BDBM93049(TLM analog, 6)
Affinity DataKd:  2.18E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93051BDBM93051(TLM analog, 8)
Affinity DataKi:  2.19E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93060BDBM93060(TLM analog, 17)
Affinity DataKd:  2.50E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93048BDBM93048(TLM analog, 5)
Affinity DataKd:  2.56E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93054BDBM93054(TLM analog, 11)
Affinity DataKd:  2.64E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93051BDBM93051(TLM analog, 8)
Affinity DataKd:  3.14E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93060BDBM93060(TLM analog, 17)
Affinity DataKi:  3.20E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93053BDBM93053(TLM analog, 10)
Affinity DataKd:  3.43E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93045BDBM93045(TLM analog, 2)
Affinity DataKi:  4.69E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93052BDBM93052(TLM analog, 9)
Affinity DataKd:  6.50E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93050BDBM93050(TLM analog, 7)
Affinity DataKi:  6.52E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93050BDBM93050(TLM analog, 7)
Affinity DataKd:  6.58E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93058BDBM93058(TLM analog, 15)
Affinity DataKd:  6.82E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93057BDBM93057(TLM analog, 14)
Affinity DataKi:  6.90E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93057BDBM93057(TLM analog, 14)
Affinity DataKd:  7.06E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93058BDBM93058(TLM analog, 15)
Affinity DataKi:  7.74E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93056BDBM93056(TLM analog, 13)
Affinity DataKi:  9.28E+4nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50180130BDBM50180130(3,5-dimethyl-4-hydroxy-5-tridecyl-5H-thiophen-2-on...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50180127BDBM50180127(3,5-dimethyl-4-hydroxy-5-tetradecyl-5H-thiophen-2-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93053BDBM93053(TLM analog, 10)
Affinity DataKi:  1.02E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93052BDBM93052(TLM analog, 9)
Affinity DataKi:  1.05E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 214777BDBM214777(TLM18)
Affinity DataKd:  1.12E+5nMpH: 8.5Assay Description:Binding of TLM18 to wild-type and mutant KasA was quantified by monitoring changes in the intrinsic tryptophan fluorescence of the enzyme at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93055BDBM93055(TLM analog, 12)
Affinity DataKd:  1.28E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93045BDBM93045(TLM analog, 2)
Affinity DataKd:  1.47E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93056BDBM93056(TLM analog, 13)
Affinity DataKd:  1.50E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 50241313BDBM50241313((R)-(+)-Thiolactomycin | (5R)-4-hydroxy-3,5-dimeth...)
Affinity DataKi:  1.75E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241313BDBM50241313((R)-(+)-Thiolactomycin | (5R)-4-hydroxy-3,5-dimeth...)
Affinity DataKd:  2.26E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93047BDBM93047(TLM analog, 4)
Affinity DataKd:  2.33E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93047BDBM93047(TLM analog, 4)
Affinity DataKi:  3.05E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidad Aut£Noma De Nuevo Le£N

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 93046BDBM93046(TLM analog, 3)
Affinity DataKd:  3.30E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93046BDBM93046(TLM analog, 3)
Affinity DataKi:  3.57E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1 [C171Q](Mycobacterium tuberculosis)
University of Wuerzburg

LigandChemical structure of BindingDB Monomer ID 214777BDBM214777(TLM18)
Affinity DataKi:  3.84E+5nMpH: 8.5Assay Description:Binding of TLM18 to wild-type and mutant KasA was quantified by monitoring changes in the intrinsic tryptophan fluorescence of the enzyme at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Institute For Chemical Biology & Drug Discovery

LigandChemical structure of BindingDB Monomer ID 93055BDBM93055(TLM analog, 12)
Affinity DataKi: >4.00E+5nMpH: 8.5Assay Description:Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50180128BDBM50180128(5-((E)-buta-1,3-dienyl)-3,5-dimethyl-4-hydroxy-5H-...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50180135BDBM50180135((R)-3,5-dimethyl-4-hydroxy-5-((1E,3E)-2-methylpent...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50180104BDBM50180104(3,5-dimethyl-4-hydroxy-5-undecyl-5H-thiophen-2-one...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 1(Escherichia coli (strain K12))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50180121BDBM50180121(3,5-dimethyl-5-(2-ethylhexyl)-4-hydroxy-5H-thiophe...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against FabB from Escherichia coli ANSIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
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