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Report error Found 475 Enz. Inhib. hit(s) with Target = 'Beta-adrenergic receptor kinase 1'
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257447(CHEMBL4073882)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257340(CHEMBL4072828)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257343(CHEMBL4086046)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataKd:  2nMAssay Description:Binding affinity to full length human GRK2 by Thermofluor thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257445(CHEMBL4095659)
Affinity DataIC50: 3nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257426(CHEMBL4077447)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257330(CHEMBL4071398)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554257(CHEMBL4742990)
Affinity DataIC50: 6nMAssay Description:Inhibition of human GRK2 by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257328(CHEMBL4082775)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257342(CHEMBL4103972)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257365(CHEMBL4083276)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257341(CHEMBL4094447)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554266(CHEMBL4785990)
Affinity DataIC50: 9nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257344(CHEMBL4065690)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554268(CHEMBL4745381)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554267(CHEMBL4760734)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50: 11nMAssay Description:Inhibition of human GRK2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257389(CHEMBL4093075)
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554276(CHEMBL4753687)
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257429(CHEMBL4061438)
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257425(CHEMBL4060973)
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554274(CHEMBL4782910)
Affinity DataIC50: 13nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 13.9nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257409(CHEMBL4087117)
Affinity DataIC50: 14nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257366(CHEMBL4082559)
Affinity DataIC50: 14nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257329(CHEMBL4064232)
Affinity DataIC50: 16nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257424(CHEMBL4082853)
Affinity DataIC50: 17nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554272(CHEMBL4751285)
Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50624682(CHEMBL5414047)
Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257390(CHEMBL4082805)
Affinity DataIC50: 19nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50554258(CHEMBL4744858)
Affinity DataIC50: 19nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM258597(US9493490, Example 9 | US9493490, F)
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM258594(US9493490, Example 3 | US9493490, 6-(4-(1-aminoeth...)
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50173319(CHEMBL3809020 | US10023564, Example 11)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin) in presence of ATP at 5 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM258596(US9493490, Example 5 | US9493490, 6-(4-(1-aminoeth...)
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257369(CHEMBL4082713)
Affinity DataIC50: 20nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 20nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257503(CHEMBL4067877)
Affinity DataIC50: 21nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257387(CHEMBL4075063)
Affinity DataIC50: 23nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257410(CHEMBL4089087)
Affinity DataIC50: 24nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2019
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 30nMAssay Description:Inhibition of human GRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM258600(US9493490, Example 12 | US9493490, 6-(3-(aminometh...)
Affinity DataIC50: 30nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

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