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Found 23 Enz. Inhib. hit(s) with Target = 'Cathepsin Z'
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataIC50: >10nMAssay Description:Inhibition of cathepsin ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50:  316nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  933nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Rattus norvegicus)
Stanford University

LigandPNGBDBM36325(Cathepsin Inhibitor III)
Affinity DataIC50:  1.50E+3nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303417(4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1...)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Rattus norvegicus)
Stanford University

LigandPNGBDBM36331(Ac-YFR-AMOK 10b)
Affinity DataIC50:  4.70E+3nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303410(4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5...)
Affinity DataIC50:  6.46E+3nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551801(CHEMBL4754916)
Affinity DataIC50:  7.13E+3nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551800(CHEMBL4743093)
Affinity DataIC50:  9.54E+3nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin Z after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551796(CHEMBL4798763)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551797(CHEMBL1331625)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551798(CHEMBL4752735)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551799(CHEMBL4744124)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Rattus norvegicus)
Stanford University

LigandPNGBDBM36330(AC-YFG-AMOK 10a)
Affinity DataIC50:  3.90E+4nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed