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Report error Found 1373 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2'
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280960BDBM50280960(9-(3,4-Dimethoxy-phenyl)-8H-furo[3',4':6,7]naphtho...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633982BDBM50633982(CHEBI:42053 | NEMORUBICIN)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 58490BDBM58490(SMR000466355 | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 43839BDBM43839(Acid, 8)
Affinity DataIC50: 3nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449890BDBM50449890(CHEMBL4161876)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50142519BDBM50142519(N-[2-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50368352BDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 10nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TOP2A in human 90-8TL cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449891BDBM50449891(CHEMBL4174756)
Affinity DataIC50: 13nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 17nMAssay Description:Inhibition of TOP2A in human ST88-14 cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470378BDBM50470378(CHEMBL108283)
Affinity DataIC50: 20nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 26nMAssay Description:Inhibition of TOP2A in human STS26T cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50410828BDBM50410828(CHEMBL5266387)
Affinity DataIC50: 26nMAssay Description:Inhibition of human DNA topoisomerase 2-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21690BDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataEC50:  30nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520631BDBM50520631(Ametantrone)
Affinity DataIC50: 30nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449889BDBM50449889(CHEMBL4160802)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 41nMAssay Description:Inhibition of TOP2A in human T265 cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470365BDBM50470365(CHEMBL326664)
Affinity DataIC50: 45nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  54nMAssay Description:Binding affinity to human TOP2A incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470374BDBM50470374(CHEMBL322325)
Affinity DataIC50: 54nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  56nMAssay Description:Binding affinity to human TOP2A incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50123623BDBM50123623((R)-13-(3-aminopyrrolidin-1-yl)-12-fluoro-10-oxo-1...)
Affinity DataIC50: 60nMAssay Description:Induction of poison effect at DNA topoisomerase 2 by G-quadruplex interaction polymerase stop assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470371BDBM50470371(CHEMBL325543)
Affinity DataIC50: 63nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127140BDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50489101BDBM50489101(CHEMBL2296491)
Affinity DataIC50: 76nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449888BDBM50449888(CHEMBL4172196)
Affinity DataIC50: 81nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213799BDBM50213799(CHEMBL440642)
Affinity DataEC50:  96nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213803BDBM50213803(CHEMBL428339)
Affinity DataEC50:  98nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449887BDBM50449887(CHEMBL4169404)
Affinity DataIC50: 110nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470361BDBM50470361(CHEMBL108404)
Affinity DataIC50: 116nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 124nMAssay Description:Inhibition of TOP2A in human SNF96.2 cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50489098BDBM50489098(CHEMBL2296492)
Affinity DataIC50: 125nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50547613BDBM50547613(CHEMBL4751362)
Affinity DataIC50: 130nMAssay Description:Inhibition of Topoisomerase II beta (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50489096BDBM50489096(CHEMBL2296490)
Affinity DataIC50: 132nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50142517BDBM50142517(N-[4-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473498BDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473498BDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213805BDBM50213805(CHEMBL7877)
Affinity DataEC50:  160nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213812BDBM50213812(CHEMBL269139)
Affinity DataEC50:  160nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505835BDBM50505835(CHEMBL4463643)
Affinity DataIC50: 200nMAssay Description:Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50142507BDBM50142507(N-[3-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 220nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470369BDBM50470369(CHEMBL325588)
Affinity DataIC50: 226nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525581BDBM50525581(CHEMBL4469453)
Affinity DataIC50: 230nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471898BDBM50471898(CHEMBL135778)
Affinity DataIC50: 240nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473499BDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 326nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214091BDBM50214091(CHEMBL27233)
Affinity DataEC50:  330nMAssay Description:In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50213795BDBM50213795(CHEMBL268458)
Affinity DataEC50:  330nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214091BDBM50214091(CHEMBL27233)
Affinity DataEC50:  330nMAssay Description:Inhibition of topoisomerase II purified from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2018
Entry Details

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50487880BDBM50487880(CHEMBL2260090)
Affinity DataIC50: 350nMAssay Description:Inhibition of Homo sapiens (human) topoisomerase 2 assessed as decatenation of KDNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

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