Compile Data Set for Download or QSAR
Report error Found 120 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1/2'
LigandChemical structure of BindingDB Monomer ID 50531540BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50222709BDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 520651BDBM520651(US11147816, PD318088 | US11701360, PD318088)
Affinity DataIC50: 1.40nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50531540BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK 1/2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50222709BDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50531540BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 2.16nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50476830BDBM50476830(CHEMBL442235)
Affinity DataIC50: 4nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476834BDBM50476834(CHEMBL234887)
Affinity DataIC50: 5nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484545BDBM50484545(CHEMBL1933935)
Affinity DataIC50: 6nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484549BDBM50484549(CHEMBL1933934)
Affinity DataIC50: 7nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 520648BDBM520648(US11147816, AZD8330 | US11701360, AZD8330)
Affinity DataIC50: 7nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50484550BDBM50484550(CHEMBL1933937)
Affinity DataIC50: 8nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484551BDBM50484551(CHEMBL1933928)
Affinity DataIC50: 9nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50094464BDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MEK in human A375 cells assessed as inhibition of ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484543BDBM50484543(CHEMBL1933932)
Affinity DataIC50: 9nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50094464BDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MEK in human A375 cells assessed as inhibition of ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 520649BDBM520649(US11147816, Binimetinib (ARRY-162, ARRY-438162) | ...)
Affinity DataIC50: 12nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50484555BDBM50484555(CHEMBL1933923)
Affinity DataIC50: 13nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataIC50: 13.7nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50484552BDBM50484552(CHEMBL1933931)
Affinity DataIC50: 14nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484547BDBM50484547(CHEMBL1933938)
Affinity DataIC50: 14nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK 1/2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50132260BDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476829BDBM50476829(CHEMBL396548)
Affinity DataIC50: 17nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476834BDBM50476834(CHEMBL234887)
Affinity DataIC50: 18nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484542BDBM50484542(CHEMBL1933929)
Affinity DataIC50: 18nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476826BDBM50476826(CHEMBL243457)
Affinity DataIC50: 21nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484553BDBM50484553(CHEMBL1933936)
Affinity DataIC50: 22nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50476830BDBM50476830(CHEMBL442235)
Affinity DataIC50: 23nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484540BDBM50484540(CHEMBL1933926)
Affinity DataIC50: 28nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476829BDBM50476829(CHEMBL396548)
Affinity DataIC50: 30nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50484546BDBM50484546(CHEMBL1933076)
Affinity DataIC50: 42nMAssay Description:Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50132260BDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataIC50: 46nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476841BDBM50476841(CHEMBL234890)
Affinity DataIC50: 61nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476825BDBM50476825(CHEMBL397811)
Affinity DataIC50: 63nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476816BDBM50476816(CHEMBL387574)
Affinity DataIC50: 68nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476816BDBM50476816(CHEMBL387574)
Affinity DataIC50: 84nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476845BDBM50476845(CHEMBL393282)
Affinity DataIC50: 91nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476839BDBM50476839(CHEMBL393283)
Affinity DataIC50: 93nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476841BDBM50476841(CHEMBL234890)
Affinity DataIC50: 95nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50498018BDBM50498018(CHEMBL3326331)
Affinity DataIC50: 97nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476826BDBM50476826(CHEMBL243457)
Affinity DataIC50: 100nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476815BDBM50476815(CHEMBL396631)
Affinity DataIC50: 100nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476833BDBM50476833(CHEMBL391975)
Affinity DataIC50: 110nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476819BDBM50476819(CHEMBL235780)
Affinity DataIC50: 120nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476842BDBM50476842(CHEMBL233627)
Affinity DataIC50: 150nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50010462BDBM50010462(CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...)
Affinity DataIC50: 160nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 26198BDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 160nMAssay Description:Inhibition of mitogen-activated protein kinase ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476831BDBM50476831(CHEMBL395231)
Affinity DataIC50: 180nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
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