Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2'
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036694BDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036687BDBM50036687((E)-3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036698BDBM50036698(3-[3-(2-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-m...)
Affinity DataIC50: 250nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50404281BDBM50404281(CHEMBL2111784)
Affinity DataIC50: 280nMAssay Description:Inhibition of human HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50289961BDBM50289961(Pentanedioic acid furan-2-ylmethyl ester 4-((E)-2-...)
Affinity DataIC50: 290nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036691BDBM50036691(3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5...)
Affinity DataIC50: 350nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50289957BDBM50289957(Pentanedioic acid 4-((E)-2-nitro-vinyl)-phenyl est...)
Affinity DataIC50: 420nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036688BDBM50036688(2-[5-((E)-2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-m...)
Affinity DataIC50: 450nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036679BDBM50036679(2-Cyano-3-[4-hydroxy-3-methoxy-5-(pyridin-2-ylsulf...)
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50289964BDBM50289964(Pentanedioic acid 4-methoxy-phenyl ester 4-((E)-2-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036686BDBM50036686(3-(3-Benzylsulfanylmethyl-4,5-dihydroxy-phenyl)-2-...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50148690BDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036700BDBM50036700(3-[3-(Benzooxazol-2-ylsulfanylmethyl)-4-hydroxy-5-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036701BDBM50036701(2-Cyano-3-[4-hydroxy-3-(4-hydroxy-phenylsulfanylme...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036680BDBM50036680(2-Cyano-3-(4-hydroxy-3-methoxy-5-p-tolylsulfanylme...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50289963BDBM50289963(Pentanedioic acid (2R,5R)-5-(6-amino-purin-9-yl)-3...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036681BDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036689BDBM50036689(2-(4-Hydroxy-3-methoxy-5-phenylsulfanylmethyl-benz...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036685BDBM50036685(3-[3-(4-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-m...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036702BDBM50036702((E)-3-[3-(2-Acetylamino-phenylsulfanylmethyl)-4-hy...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036690BDBM50036690(2-Cyano-3-[4-hydroxy-3-methoxy-5-(naphthalen-2-yls...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214741BDBM50214741(CHEMBL65096)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036697BDBM50036697((E)-3-[3-(1H-Benzoimidazol-2-ylsulfanylmethyl)-4-h...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036678BDBM50036678(3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-phen...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036695BDBM50036695(2-[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzy...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036692BDBM50036692(3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4,5-dihydro...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214742BDBM50214742(CHEMBL302905)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214739BDBM50214739(CHEMBL68413)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50148694BDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50148692BDBM50148692(Cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-(4-methyl-pi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214743BDBM50214743(CHEMBL63650)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214738BDBM50214738(CHEMBL65594)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214737BDBM50214737(CHEMBL63772)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214740BDBM50214740(CHEMBL67009)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ligand-stimulated autophosphorylation of EGFR/HER2 chimeric receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036683BDBM50036683(3-[3-(5-Chloro-benzothiazol-2-ylsulfanylmethyl)-4-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036704BDBM50036704(4-[5-(2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-metho...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036696BDBM50036696(2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl...)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036684BDBM50036684(2-(3,4-Dihydroxy-5-methyl-benzylidene)-malononitri...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036682BDBM50036682([5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzyls...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50036699BDBM50036699(2-(4-Hydroxy-3-methoxy-5-methyl-benzylidene)-malon...)
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed