Compile Data Set for Download or QSAR
Report error Found 2591 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E'
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525088BDBM50525088(CHEMBL4461497)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525089BDBM50525089(CHEMBL4464315)
Affinity DataKd:  0.0460nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545290BDBM545290(US11286268, Compound 778)
Affinity DataIC50: 0.0700nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36609BDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to purified elF4EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545157BDBM545157(US11286268, Compound 643)
Affinity DataIC50: 0.832nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545209BDBM545209(US11286268, Compound 695)
Affinity DataIC50: 1.05nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544933BDBM544933(US11286268, Compound 419)
Affinity DataIC50: 1.08nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545525BDBM545525(US11286268, Compound 1016)
Affinity DataIC50: 1.11nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545738BDBM545738(US11286268, Compound 1228)
Affinity DataIC50: 1.11nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544886BDBM544886(US11286268, Compound 369)
Affinity DataIC50: 1.32nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544980BDBM544980(US11286268, Compound 465 | US11286268, Compound 93...)
Affinity DataIC50: 1.36nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545407BDBM545407(US11286268, Compound 897)
Affinity DataIC50: 1.40nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263263BDBM50263263(CHEMBL4073443)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Ser 209 phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545578BDBM545578(US11286268, Compound 1069)
Affinity DataIC50: 1.52nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545153BDBM545153(US11286268, Compound 896 | US11286268, Compound 63...)
Affinity DataIC50: 1.57nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545153BDBM545153(US11286268, Compound 896 | US11286268, Compound 63...)
Affinity DataIC50: 1.57nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544904BDBM544904(US11286268, Compound 390)
Affinity DataIC50: 1.75nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545084BDBM545084(US11286268, Compound 569)
Affinity DataIC50: 2nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 546104BDBM546104(US11286268, Compound 1603)
Affinity DataIC50: 2.12nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565476BDBM50565476(CHEMBL4780117)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544984BDBM544984(US11286268, Compound 469)
Affinity DataIC50: 2.25nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545105BDBM545105(US11286268, Compound 590)
Affinity DataIC50: 2.26nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545347BDBM545347(US11286268, Compound 836)
Affinity DataIC50: 2.33nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545511BDBM545511(US11286268, Compound 1002)
Affinity DataIC50: 2.37nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545447BDBM545447(US11286268, Compound 938)
Affinity DataIC50: 2.44nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545305BDBM545305(US11286268, Compound 792)
Affinity DataIC50: 2.44nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545130BDBM545130(US11286268, Compound 616)
Affinity DataIC50: 2.45nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545733BDBM545733(US11286268, Compound 1223)
Affinity DataIC50: 2.79nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544884BDBM544884(US11286268, Compound 367)
Affinity DataIC50: 2.87nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544953BDBM544953(US11286268, Compound 439a)
Affinity DataIC50: 2.87nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544834BDBM544834(US11286268, Compound 318)
Affinity DataIC50: 2.92nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545132BDBM545132(US11286268, Compound 618)
Affinity DataIC50: 2.98nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545732BDBM545732(US11286268, Compound 1222)
Affinity DataIC50: 3.02nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545168BDBM545168(US11286268, Compound 654)
Affinity DataIC50: 3.12nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545735BDBM545735(US11286268, Compound 1225)
Affinity DataIC50: 3.12nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545293BDBM545293(US11286268, Compound 781)
Affinity DataIC50: 3.12nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545471BDBM545471(US11286268, Compound 962)
Affinity DataIC50: 3.15nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545217BDBM545217(US11286268, Compound 703)
Affinity DataIC50: 3.18nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597686BDBM50597686(CHEMBL5183975)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545418BDBM545418(US11286268, Compound 908)
Affinity DataIC50: 3.26nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545309BDBM545309(US11286268, Compound 796)
Affinity DataIC50: 3.27nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545327BDBM545327(US11286268, Compound 815)
Affinity DataIC50: 3.31nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545473BDBM545473(US11286268, Compound 964)
Affinity DataIC50: 3.32nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545212BDBM545212(US11286268, Compound 698)
Affinity DataIC50: 3.40nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545145BDBM545145(US11286268, Compound 631)
Affinity DataIC50: 3.41nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545307BDBM545307(US11286268, Compound 794)
Affinity DataIC50: 3.41nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545545BDBM545545(US11286268, Compound 1036)
Affinity DataIC50: 3.51nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 544905BDBM544905(US11286268, Compound 391)
Affinity DataIC50: 3.52nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545475BDBM545475(US11286268, Compound 966)
Affinity DataIC50: 3.58nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 545319BDBM545319(US11286268, Compound 806)
Affinity DataIC50: 3.58nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

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