Compile Data Set for Download or QSAR
Report error Found 940 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1/2B'
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474799BDBM50474799(CHEMBL416690)
Affinity DataKi:  0.400nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451786BDBM50451786(CHEMBL423244)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451785BDBM50451785(CHEMBL159675)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474791BDBM50474791(CHEMBL65693)
Affinity DataKi:  0.680nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124885BDBM50124885(N-(2-methoxybenzyl)cinnamamidine | (E)-N-(2-Methox...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451505BDBM50451505(CHEMBL274422)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474791BDBM50474791(CHEMBL65693)
Affinity DataIC50: 0.720nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451789BDBM50451789(CHEMBL159762)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474809BDBM50474809(CHEMBL65454)
Affinity DataKi:  0.820nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474789BDBM50474789(CHEMBL68134)
Affinity DataKi:  0.850nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451766BDBM50451766(CHEMBL159761)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474796BDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474796BDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451778BDBM50451778(CHEMBL159416)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451772BDBM50451772(CHEMBL159453)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451769BDBM50451769(CHEMBL159902)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143890BDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR1a/NR2b receptor expressed in mouse Ltk cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143890BDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451784BDBM50451784(CHEMBL159790)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451779BDBM50451779(CHEMBL160027)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451503BDBM50451503(CHEMBL12513)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451780BDBM50451780(CHEMBL161859)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 409275BDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 2nMAssay Description:Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50140341BDBM50140341(6-(3-(4-(4-fluorobenzyl)piperidin-1-yl)prop-1-ynyl...)
Affinity DataIC50: 2nMAssay Description:Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502547BDBM50502547(CHEMBL4581662)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149693BDBM50149693(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474808BDBM50474808(CHEMBL65314)
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451764BDBM50451764(CHEMBL159425)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149695BDBM50149695(2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dih...)
Affinity DataIC50: 3nMAssay Description:Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50091636BDBM50091636(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50: 3nMAssay Description:Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474808BDBM50474808(CHEMBL65314)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474792BDBM50474792(CHEMBL63200)
Affinity DataKi:  3.20nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331292BDBM50331292((+/-)-cis-3-(4-Phenylcyclohexyl)-2,3,4,5-tetrahydr...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451770BDBM50451770(CHEMBL350614)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149684BDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149684BDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity against NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149695BDBM50149695(2-(4-Benzyl-piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dih...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-Ro-256981 from recombinant NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50140339BDBM50140339(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Affinity DataIC50: 4nMAssay Description:Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474790BDBM50474790(CHEMBL303832)
Affinity DataKi:  4.20nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370772BDBM370772(US10239835, Example 00324)
Affinity DataIC50: 4.41nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2B (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370754BDBM370754(US10239835, Example 00306)
Affinity DataIC50: 4.44nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2B (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50079385BDBM50079385(1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502557BDBM50502557(CHEMBL4459690)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149693BDBM50149693(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-Ro-256981 from recombinant NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502554BDBM50502554(CHEMBL4533030)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370814BDBM370814(US10239835, Example 00365)
Affinity DataIC50: 5.24nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2B (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

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