Compile Data Set for Download or QSAR
Report error Found 2677 Enz. Inhib. hit(s) with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit epsilon'
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.199nMAssay Description:Inhibition of human IKKepsilon using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276896BDBM276896(US10072001, Example 82 | US10259811, Example 82)
Affinity DataIC50: 0.290nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276896BDBM276896(US10072001, Example 82 | US10259811, Example 82)
Affinity DataIC50: 0.290nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.439nMAssay Description:Inhibition of human IKKepsilon using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276969BDBM276969(US10072001, Example 145 | US10259811, Example 145)
Affinity DataIC50: 0.481nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276969BDBM276969(US10072001, Example 145 | US10259811, Example 145)
Affinity DataIC50: 0.481nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276965BDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50: 0.687nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276965BDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50: 0.687nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276877BDBM276877(US10072001, Example 63 | US10259811, Example 63)
Affinity DataIC50: 0.710nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276877BDBM276877(US10072001, Example 63 | US10259811, Example 63)
Affinity DataIC50: 0.710nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276879BDBM276879(US10072001, Example 65 | US10259811, Example 65)
Affinity DataIC50: 0.770nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276879BDBM276879(US10072001, Example 65 | US10259811, Example 65)
Affinity DataIC50: 0.770nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276868BDBM276868(US10072001, Example 54 | US10259811, Example 54)
Affinity DataIC50: 0.810nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276868BDBM276868(US10072001, Example 54 | US10259811, Example 54)
Affinity DataIC50: 0.810nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 277059BDBM277059(US10072001, Example 251 | US10259811, Example 251)
Affinity DataIC50: 0.815nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 277059BDBM277059(US10072001, Example 251 | US10259811, Example 251)
Affinity DataIC50: 0.815nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 277037BDBM277037(US10072001, Example 229 | US10259811, Example 229)
Affinity DataIC50: 0.851nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 277037BDBM277037(US10072001, Example 229 | US10259811, Example 229)
Affinity DataIC50: 0.851nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278079BDBM278079((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278238BDBM278238(2-(((S)-3,3-difluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278323BDBM278323(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278082BDBM278082((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278083BDBM278083(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278074BDBM278074(2-(((3R,4S)-3-fluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 375573BDBM375573(5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278247BDBM278247(2-(((S)-3,3-difluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278084BDBM278084(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278161BDBM278161(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278080BDBM278080((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278081BDBM278081((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278080BDBM278080((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278167BDBM278167(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278338BDBM278338((S)-2-((3,3-difluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278081BDBM278081((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278162BDBM278162(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278333BDBM278333(2-(((3R,4S)-1-((S)-2,3-dihydroxypropanoyl)-3-fluor...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278079BDBM278079((S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278171BDBM278171(5-(4-((3-(difluoromethoxy)-4-(4-(oxetan-3-yl)piper...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278085BDBM278085(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278256BDBM278256((3R,4S)-4-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)pipera...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278170BDBM278170(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278087BDBM278087(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278172BDBM278172(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278086BDBM278086(2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278257BDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278083BDBM278083(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278339BDBM278339(2-(((S)-3,3-difluoro-1-((S)-2-hydroxypropanoyl)pip...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278082BDBM278082((S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278015BDBM278015(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278007BDBM278007(2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

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