Compile Data Set for Download or QSAR
Report error Found 979 Enz. Inhib. hit(s) with Target = 'Inosine-5'-monophosphate dehydrogenase 2'
LigandChemical structure of BindingDB Monomer ID 248094BDBM248094(VX-497 (2))
Affinity DataIC50: 3.5nMpH: 8.0 T: 2°CAssay Description:The assay was performed in a 100 μL final volume in 96-well UV plates (Costar, 3635) with a reaction buffer composed of 50 mM Tris-HCl (pH 8.0), 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123358BDBM50123358(7-Methoxy-2-(4-methyl-3-morpholin-4-yl-phenyl)-6-o...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123333BDBM50123333(2-(4-Bromo-phenyl)-7-methoxy-6-oxazol-5-yl-1H-quin...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123355BDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123355BDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123332BDBM50123332(7-Methoxy-2-(4-methoxy-phenyl)-6-oxazol-5-yl-1H-qu...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50222630BDBM50222630(CHEMBL153481)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50126275BDBM50126275(Isoquinolin-6-yl-(5-phenyl-oxazol-2-yl)-amine | CH...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50222633BDBM50222633(CHEMBL356881)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123335BDBM50123335(2-(3,4-Dimethyl-phenyl)-7-methoxy-6-oxazol-5-yl-1H...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123321BDBM50123321(7-Methoxy-6-oxazol-5-yl-2-m-tolyl-1H-quinolin-4-on...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123317BDBM50123317(7-Methoxy-6-oxazol-5-yl-2-p-tolyl-1H-quinolin-4-on...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50123355BDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123353BDBM50123353(2-(3-Azetidin-1-yl-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50133731BDBM50133731({3-[3-(4-Cyano-3-methoxy-phenyl)-ureido]-benzyl}-c...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  7nMAssay Description:Inhibition of human IMPDH2 by SpectrophotometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50120529BDBM50120529(Acetic acid (methyl-{2-[2-(3-oxazol-5-yl-1H-indol-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50120529BDBM50120529(Acetic acid (methyl-{2-[2-(3-oxazol-5-yl-1H-indol-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123324BDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 19284BDBM19284(N-{2-[3-(dimethylsulfamoyl)phenyl]propan-2-yl}-2-f...)
Affinity DataIC50: 7.90nM EC50:  380nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123324BDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataIC50: 8nMAssay Description:Inhibition of inosine-5'-monophosphate dehydrogenase 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123324BDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataIC50: 8nMAssay Description:Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123324BDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50054042BDBM50054042((E)-6-(4-Hydroxy-7-methyl-3-oxo-6-vinyl-1,3-dihydr...)
Affinity DataIC50: 8.51nMAssay Description:Inhibition of human recombinant inosine monophosphate dehydrogenase type II. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123320BDBM50123320(7-Methoxy-6-oxazol-5-yl-2-thiophen-3-yl-1H-quinoli...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 19283BDBM19283(N-{2-[4-(dimethylsulfamoyl)phenyl]propan-2-yl}-2-f...)
Affinity DataIC50: 10nM EC50:  660nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  10nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50102249BDBM50102249({3-[3-(3-Methoxy-4-oxazol-5-yl-phenyl)-ureido]-ben...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50112565BDBM50112565(N-tert-Butyl-N'-(3-methoxy-4-oxazol-5-yl-phenyl)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of inosine-5'-monophosphate dehydrogenase 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  10nMAssay Description:Inhibition of human IMP dehydrogenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50102249BDBM50102249({3-[3-(3-Methoxy-4-oxazol-5-yl-phenyl)-ureido]-ben...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataKi:  10nMAssay Description:Inhibition of human IMPDH 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50112565BDBM50112565(N-tert-Butyl-N'-(3-methoxy-4-oxazol-5-yl-phenyl)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50222632BDBM50222632(CHEMBL356236)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50113219BDBM50113219(N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phenylamino)-oxaz...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50120535BDBM50120535(1-(3-Oxazol-5-yl-1H-indol-6-yl)-3-p-tolyl-urea | C...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50123350BDBM50123350(Dimethyl-carbamic acid 6-(7-methoxy-6-oxazol-5-yl-...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19277BDBM19277(2-fluoro-9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydr...)
Affinity DataIC50: 11nM EC50:  830nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19292BDBM19292(2-fluoro-N-{2-[5-methyl-6-(morpholin-4-yl)pyridin-...)
Affinity DataIC50: 11nM EC50:  870nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50120535BDBM50120535(1-(3-Oxazol-5-yl-1H-indol-6-yl)-3-p-tolyl-urea | C...)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19279BDBM19279(2-fluoro-9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,1...)
Affinity DataIC50: 11nM EC50:  420nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50102249BDBM50102249({3-[3-(3-Methoxy-4-oxazol-5-yl-phenyl)-ureido]-ben...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 19282BDBM19282(2-fluoro-N-[2-(3-methanesulfonylphenyl)propan-2-yl...)
Affinity DataIC50: 12nM EC50:  580nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 19264BDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50123376BDBM50123376(7-Methoxy-2-(3-methylamino-indan-5-yl)-6-oxazol-5-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50113230BDBM50113230(BMS-337197 | N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phen...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
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