Compile Data Set for Download or QSAR
Report error Found 1609 Enz. Inhib. hit(s) with Target = 'Integrin alpha-V/beta-6'
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464108BDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to human integrin alphaVbeta6 assessed as dissociation constant up to 48 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464108BDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.0158nMAssay Description:Binding affinity to human integrin alphaVbeta6 after 24 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464108BDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to human integrin alphaVbeta6 after 24 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464104BDBM50464104(CHEMBL4244784)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464110BDBM50464110(CHEMBL4238909)
Affinity DataKi:  0.0251nMAssay Description:Binding affinity to human integrin alphaVbeta6 assessed as dissociation constant up to 48 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464123BDBM50464123(CHEMBL4242263)
Affinity DataKi:  0.0316nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464124BDBM50464124(CHEMBL4249629)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464118BDBM50464118(CHEMBL4249172)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464119BDBM50464119(CHEMBL4241584)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464108BDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0398nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464108BDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110227BDBM50110227(CHEMBL267434 | CHEMBL2332368 | 3-{2-[4-(4-Methyl-p...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110227BDBM50110227(CHEMBL267434 | CHEMBL2332368 | 3-{2-[4-(4-Methyl-p...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by Merck binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464120BDBM50464120(CHEMBL4237919)
Affinity DataKi:  0.0501nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464100BDBM50464100(CHEMBL4243367)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464097BDBM50464097(CHEMBL4237868)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464113BDBM50464113(CHEMBL4239085)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464110BDBM50464110(CHEMBL4238909)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464112BDBM50464112(CHEMBL4248589)
Affinity DataKi:  0.0794nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464115BDBM50464115(CHEMBL4247149)
Affinity DataKi:  0.0794nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464098BDBM50464098(CHEMBL4242635)
Affinity DataKi:  0.0794nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464102BDBM50464102(CHEMBL4251444)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519160BDBM50519160(CHEMBL4468357)
Affinity DataKi:  0.107nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110228BDBM50110228(3-{2-[4-(4-Methyl-pyridin-2-ylamino)-butyrylamino]...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464108BDBM50464108(CHEMBL4241824)
Affinity DataEC50:  0.158nMAssay Description:Induction of integrin alphaVbeta6 receptor internalization in human primary human lung epithelial cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519162BDBM50519162(CHEMBL4573716)
Affinity DataKi:  0.174nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279573BDBM279573((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565948BDBM50565948(CHEMBL4780301)
Affinity DataIC50: 0.260nMAssay Description:Binding affinity to human integrin alphaVbeta6 incubated for 1 hr by ELISA based solid phase integrin binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50530099BDBM50530099(CHEMBL4441624)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50530099BDBM50530099(CHEMBL4441624)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279561BDBM279561((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279568BDBM279568((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279566BDBM279566((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279569BDBM279569((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279563BDBM279563((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110236BDBM50110236(3-(3,5-Dichloro-phenyl)-3-{2-[5-(4-methyl-pyridin-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279562BDBM279562((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279560BDBM279560((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279567BDBM279567((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279565BDBM279565((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279572BDBM279572((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279570BDBM279570((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279575BDBM279575((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279564BDBM279564((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 606867BDBM606867(US11685738, Compound A3)
Affinity DataIC50: 0.570nMAssay Description:The full reaction (Integrin-Ligand Interaction) was optimized as above. Integrin coupled beads were taken for the experiment. 2 μL of 10 nM/20 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110232BDBM50110232(3-Biphenyl-4-yl-3-{2-[5-(pyridin-2-ylamino)-pentan...)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at alphavbeta6 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279571BDBM279571((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110232BDBM50110232(3-Biphenyl-4-yl-3-{2-[5-(pyridin-2-ylamino)-pentan...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 279574BDBM279574((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50530110BDBM50530110(CHEMBL4575627)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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