Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with Target = 'Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]'
LigandChemical structure of BindingDB Monomer ID 476529BDBM476529(N-((8 endo)-3-(3-methylisothiazol-5-yl)-3-azabicyc...)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502721BDBM50502721(CHEMBL4435639 | US11440915, Example 9)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476532BDBM476532(N-((8 endo)-3-(2-chloropyridin-4-yl)-3-azabicyclo[...)
Affinity DataEC50:  9.20nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 571405BDBM571405(US11440915, Example 20 | (9R)-N-[3-(4-methylimidaz...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476540BDBM476540(US10875854, Example 13)
Affinity DataEC50:  11.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476557BDBM476557(US10875854, Example 30)
Affinity DataEC50:  13.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502715BDBM50502715(CHEMBL4567728 | US11440915, Example 10)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502709BDBM50502709(CHEMBL4538936 | US11440915, Example 8)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 571404BDBM571404(US11440915, Example 19 | (9R)-N-[3-(4-methylimidaz...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476556BDBM476556(US10875854, Example 29)
Affinity DataEC50:  14.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502714BDBM50502714(CHEMBL4470732 | US11440915, Example 7)
Affinity DataEC50:  15nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502710BDBM50502710(CHEMBL4520800 | US11440915, Example 1)
Affinity DataEC50:  15nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476533BDBM476533(US10875854, Example 6 | N-((8 endo)-3-(2-methoxypy...)
Affinity DataEC50:  15.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502719BDBM50502719(CHEMBL4475670 | US11440915, Example 2)
Affinity DataEC50:  16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 571401BDBM571401(US11440915, Example 16 | (9R)-9-(2-fluorophenyl)-N...)
Affinity DataEC50:  19nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476555BDBM476555(US10875854, Example 28 | 8-isopropyl-N-((8 endo)-3...)
Affinity DataEC50:  19.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476530BDBM476530(8-methyl-5-(2,2,2-trifluoroethoxy)-N-((8 endo)-3-(...)
Affinity DataEC50:  20.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476548BDBM476548(US10875854, Example 21 | 3-methoxy-4-(2-methyl-4-p...)
Affinity DataEC50:  21.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476544BDBM476544(US10875854, Example 17 | (8 endo)-3-(6-methoxypyri...)
Affinity DataEC50:  21.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502713BDBM50502713(CHEMBL4468874 | US11440915, Example 6)
Affinity DataEC50:  23nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476542BDBM476542(US10875854, Example 15)
Affinity DataEC50:  23.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502711BDBM50502711(CHEMBL4515522 | US11440915, Example 3)
Affinity DataEC50:  25nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476541BDBM476541(US10875854, Example 14)
Affinity DataEC50:  25.4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502712BDBM50502712(CHEMBL4439419 | US11440915, Example 5)
Affinity DataEC50:  26nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476546BDBM476546(US10875854, Example 19 | 3-Methoxy-4-(3-methyl-1,2...)
Affinity DataEC50:  26.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 571407BDBM571407(US11440915, Example 22 | (9R)-N-[4-(4-methylimidaz...)
Affinity DataEC50:  27nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502722BDBM50502722(CHEMBL4522681 | US11440915, Example 14)
Affinity DataEC50:  27nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476552BDBM476552(US10875854, Example 25 | 4-(4-chloroimidazol-1-yl)...)
Affinity DataEC50:  27nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476531BDBM476531(8-methyl-N-((8 endo)-3-(6-methylpyrimidin-4-yl)-3-...)
Affinity DataEC50:  29.9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502720BDBM50502720(CHEMBL4474921 | US11440915, Example 4)
Affinity DataEC50:  31nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476562BDBM476562(US10875854, Example 35 | N-[4-(4-chloroimidazol-1-...)
Affinity DataEC50:  31.4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476538BDBM476538(US10875854, Example 11 | 8-isopropyl-5-(2,2,2-trif...)
Affinity DataEC50:  33.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476543BDBM476543(US10875854, Example 16)
Affinity DataEC50:  34.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476549BDBM476549(US10875854, Example 22 | 2-[2-[[(8 endo)-3-(6-meth...)
Affinity DataEC50:  34.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476554BDBM476554(US10875854, Example 27)
Affinity DataEC50:  37.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476545BDBM476545(US10875854, Example 18 | (8-endo)-3-(3-methyl-1,2,...)
Affinity DataEC50:  37.4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 571400BDBM571400(US11440915, Example 15 | (9R)-9-(2-fluorophenyl)-N...)
Affinity DataEC50:  38nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476539BDBM476539(US10875854, Example 12)
Affinity DataEC50:  38.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502716BDBM50502716(CHEMBL4576494 | US11440915, Example 11)
Affinity DataEC50:  39nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476551BDBM476551(US10875854, Example 33 | US10875854, Example 24)
Affinity DataEC50:  39nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476551BDBM476551(US10875854, Example 33 | US10875854, Example 24)
Affinity DataEC50:  39nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476550BDBM476550(US10875854, Example 23)
Affinity DataEC50:  40nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476561BDBM476561(US10875854, Example 34 | N-[3-methoxy-4-(3-methyl-...)
Affinity DataEC50:  40.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476553BDBM476553(US10875854, Example 26 | 4-(3-chloro-1,2,4-triazol...)
Affinity DataEC50:  42.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 571406BDBM571406(US11440915, Example 21 | (9R)-N-[4-(4-methylimidaz...)
Affinity DataEC50:  43nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476559BDBM476559(US10875854, Example 32 | (8 endo)-3-(5-methyl-1,3,...)
Affinity DataEC50:  43.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476528BDBM476528(5-(2,2,2-trifluoroethoxy)-N-((8 endo)-3-(2-(triflu...)
Affinity DataEC50:  43.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476536BDBM476536(US10875854, Example 9 | 2-(2-(((8 endo)-3-(6-methy...)
Affinity DataEC50:  43.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50502717BDBM50502717(CHEMBL4461898 | US11440915, Example 13)
Affinity DataEC50:  44nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 476535BDBM476535(US10875854, Example 8 | 2-(5-(2,2,2-trifluoroethox...)
Affinity DataEC50:  44.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

Displayed 1 to 50 (of 57 total ) | Next | Last >>
Jump to: