Compile Data Set for Download or QSAR
Report error Found 5356 Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor beta'
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.0750nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.0750nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.0750nMAssay Description:Binding affinity to PDGFRBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.0800nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  0.0890nMAssay Description:Binding affinity to human PDGFRB incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664201BDBM664201(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664388BDBM664388(N-(5-(2- (cyclobutylamino)acetamido)- 2-methylpyri...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664205BDBM664205(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664200BDBM664200(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664033BDBM664033(N-(5-((2-(6-azaspiro[3.4]octan- 6-yl)ethyl)carbamo...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664241BDBM664241(N-(5-(2-(5-azaspiro[2.4]heptan- 5-yl)acetamido)-2-...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664353BDBM664353(N-(5-(2-(3,3-Dimethylazetidin- 1-yl)acetamido)-2- ...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664204BDBM664204(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664203BDBM664203(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265774BDBM50265774(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664160BDBM664160(N-(5-(3-(2,2-dimethylpyrrolidin- 1-yl)propanamido)...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265746BDBM50265746({4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 702157BDBM702157(US20240360134, Example 119)
Affinity DataIC50: 0.130nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581371BDBM581371(US11505527, Compound 4j)
Affinity DataIC50: 0.140nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 702160BDBM702160(US20240360134, Example 122)
Affinity DataIC50: 0.150nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 702120BDBM702120(US20240360134, Example 82)
Affinity DataIC50: 0.180nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 663993BDBM663993((S)-N-(5-(2-(3- ethylmorpholino)acetamido)-2- meth...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664079BDBM664079(N-(5-((2-(5-azaspiro[2.4]heptan- 5-yl)ethyl)carbam...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664333BDBM664333((S)-2-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664337BDBM664337(N-(5-(2-(azepan-1- yl)acetamido)-2-methylpyridin- ...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664378BDBM664378(N-(5-((2-(5-azaspiro[3.4]octan- 5-yl)ethyl)carbamo...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664286BDBM664286(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664161BDBM664161((R)-2-(2-methoxypyridin-3-yl)- N-(2-methyl-5-((2-(...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664202BDBM664202(N-(5-(2-(3,3-dimethylazetidin-1- yl)acetamido)-2-m...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664174BDBM664174(2-(pyrrolidin-1-yl)propyl (5-(2- (2-methoxypyridin...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664173BDBM664173(2-(2,2-dimethylpyrrolidin-1- yl)ethyl (5-(2-(2- me...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 702108BDBM702108(US20240360134, Example 70)
Affinity DataIC50: 0.200nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664391BDBM664391(N-(5-(2-(5- azaspiro[2.4]heptan-5- yl)acetamido)-2...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.200nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664218BDBM664218((S)-2-(2-methoxypyridin-3-yl)- N-(2-methyl-5-((2-(...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664347BDBM664347(2-(1,3-Dimethyl-1H-pyrazol-4- yl)-N-(5-(2-(3,3- di...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664176BDBM664176((S)-(1-methylpyrrolidin-2- yl)methyl (6-methyl-5-(...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664304BDBM664304(N-(5-((2-(3,3-dimethylazetidin- 1-yl)ethyl)carbamo...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664338BDBM664338(N-(5-(2- (cyclopentylamino)acetamido)- 2-methylpyr...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50381945BDBM50381945(CHEMBL2023477)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664339BDBM664339(N-(5-(2- (cyclopentylamino)acetamido)- 2-methylpyr...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664172BDBM664172((S)-(1-methylpyrrolidin-2- yl)methyl (5-(2-(2- met...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 702101BDBM702101(US20240360134, Example 63)
Affinity DataIC50: 0.200nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 702159BDBM702159(US20240360134, Example 121)
Affinity DataIC50: 0.200nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664270BDBM664270(N-(5-(2-(1-azaspiro[3.3]heptan- 1-yl)acetamido)-2-...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265574BDBM50265574(3-(1H-benzo[d]imidazol-2-yl)-4-(4-ethyl-1-methylpi...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664271BDBM664271(2-(1,3-dimethyl-1H-pyrazol-4- yl)-N-(5-(1-isopropy...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664399BDBM664399(2-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)- N-...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664100BDBM664100(N-(5-((2-(2- azabicyclo[2.2.2]octan-2- yl)ethyl)ca...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 664228BDBM664228((S)-N-(5-(2-(2- ethylmorpholino)acetamido)-2- meth...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

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