Compile Data Set for Download or QSAR
Report error Found 149 Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily T member 1'
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557676(CHEMBL4763955)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557672(CHEMBL4788669)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild-type human Slack expressed in HEK293 cells measured by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557678(CHEMBL4754084)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50638325(CHEMBL5558979)
Affinity DataIC50: 80nMAssay Description:Inhibition of human KCNT1 (98 to 354 residues) expressed in CHO cells at +60 mV holding potential by whole-cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557660(CHEMBL4783741)
Affinity DataIC50: 136nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557666(CHEMBL4786255)
Affinity DataIC50: 165nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557652(CHEMBL4793291)
Affinity DataIC50: 167nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557679(CHEMBL4793279)
Affinity DataIC50: 195nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50638324(CHEMBL2398613)
Affinity DataIC50: 200nMAssay Description:Inhibition of human KCNT1 (98 to 354 residues) expressed in CHO cells at +60 mV holding potential by whole-cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50638326(CHEMBL4476393)
Affinity DataIC50: 210nMAssay Description:Inhibition of human KCNT1 (98 to 354 residues) expressed in CHO cells at +60 mV holding potential by whole-cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557677(CHEMBL4750925)
Affinity DataIC50: 322nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557656(CHEMBL4783466)
Affinity DataIC50: 335nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557674(CHEMBL4795194)
Affinity DataIC50: 454nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557675(CHEMBL4743249)
Affinity DataIC50: 505nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Rat)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 545nMAssay Description:Inhibition of recombinant rat KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557673(CHEMBL4781553)
Affinity DataIC50: 573nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 622nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557682(CHEMBL4745211)
Affinity DataIC50: 744nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557683(CHEMBL4758890)
Affinity DataIC50: 778nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557659(CHEMBL4779088)
Affinity DataIC50: 977nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617447(US20230285377, Example 31)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617448(US20230285377, Example 32)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617412(US20230285377, Example 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617418(US20230285377, Example 6)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617419(US20230285377, Example 7)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617455(US20230285377, Example 39)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617413(US20230285377, Example 2)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617451(US20230285377, Example 35)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617415(US20230285377, Example 4)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617452(US20230285377, Example 36)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617416(US20230285377, Example 5)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617426(US20230285377, Example 14)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617428(US20230285377, Example 16)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617422(US20230285377, Example 10)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617423(US20230285377, Example 11)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617424(US20230285377, Example 12)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617460(US20230285377, Example 44)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617425(US20230285377, Example 13)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617461(US20230285377, Example 45)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617439(US20230285377, Example 25)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617431(US20230285377, Example 19)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM617434(US20230285377, Example 21)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KCNT1 (KNa1.1, Slack) was evaluated using a tetracycline inducible cell line (HEK-TREX). Currents were recorded using the SyncroPatch 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50607075(CHEMBL5220335)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of wild-type human Slack expressed in HEK293 cells measured by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557676(CHEMBL4763955)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557678(CHEMBL4754084)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557664(CHEMBL4750826)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50607067(CHEMBL5218475)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of wild-type human Slack expressed in HEK293 cells measured by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557670(CHEMBL4744857)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
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