Compile Data Set for Download or QSAR
Report error Found 741 Enz. Inhib. hit(s) with Target = 'Prostacyclin receptor'
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101823(4-(2-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-...)
Affinity DataKi: >0.000100nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101832((E)-7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1...)
Affinity DataKi: >0.000100nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101825((Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4...)
Affinity DataKi: >0.000100nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProstacyclin receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  0.690nMAssay Description:Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101853((13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-...)
Affinity DataEC50:  1.80nMAssay Description:Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50594971(TREPROSTINIL | CHEBI:50861 | Treprostinil | Trespr...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM357272(US10214518, Compound 198 | 2-(((1s,4s)-4-((5-(2- h...)
Affinity DataEC50:  2nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM357272(US10214518, Compound 198 | 2-(((1s,4s)-4-((5-(2- h...)
Affinity DataEC50:  2nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101848(6-[(1R,2S,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5...)
Affinity DataKi:  3.30nMAssay Description:Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235368(CHEMBL3893346)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235376(CHEMBL3926078)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235374(CHEMBL3935924)
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50103391(CHEMBL3398233)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235379(CHEMBL3932106 | US10668033, Compound 55)
Affinity DataEC50:  5.14nMAssay Description:Compounds were screened for agonists of the human prostacyclin (PGI2) receptor using the HTRF assay for direct cAMP measurement (Gabriel et al., ASSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235379(CHEMBL3932106 | US10668033, Compound 55)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235383(ACT-293987 | NS-304 | Selexipag | Uptravi)
Affinity DataEC50:  6nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50103396(CHEMBL3398236)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50168287(Sodium; {3-[(1R,2S,6S)-1-(4,5-diphenyl-oxazol-2-yl...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  6.5nMAssay Description:In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  6.5nMAssay Description:Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235375(CHEMBL3975122)
Affinity DataEC50:  6.60nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM357269(US10214518, Compound 90 | 2-(((1s,4s)-4-((5- (ethy...)
Affinity DataEC50:  7nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM357269(US10214518, Compound 90 | 2-(((1s,4s)-4-((5- (ethy...)
Affinity DataEC50:  7nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235389(CHEMBL3983767)
Affinity DataEC50:  7.80nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM464509(US10793529, Compound 69 | 2-(((1s,4s)-4-((6-(4- me...)
Affinity DataEC50:  8nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50095207([6-(4-Benzhydryl-pyrazol-1-ylmethyl)-7,8-dihydro-n...)
Affinity DataIC50: 8nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 8.40nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataEC50:  8.5nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50103405(CHEMBL3398215)
Affinity DataEC50:  8.5nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235370(CHEMBL3933704)
Affinity DataEC50:  8.70nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50167887({(R)-6-[(Diphenylcarbamoyloxy)-methyl]-6-hydroxy-5...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]iloprost from human Prostanoid IP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 9nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50103408(CHEMBL3398220)
Affinity DataEC50:  9.5nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50103394(CHEMBL3398229)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50284372({5-[2-(N',N'-Diphenyl-hydrazinocarbonyl)-ethyl]-5,...)
Affinity DataIC50: 10nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50103407(CHEMBL3398219)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50235378(CHEMBL3981509)
Affinity DataEC50:  10nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM85179(CAS_94079-80-8 | NSC_72023 | CICAPROST)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
TargetProstacyclin receptor(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50169552(CHEMBL3804978)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM357271(US10214518, Compound 184 | 2-(((1s,4s)-4-((5- (cya...)
Affinity DataEC50:  11nMAssay Description:Principle of the assay: The HTRF assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF assay supported by the ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

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