Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase LCK'
LigandChemical structure of BindingDB Monomer ID 26166BDBM26166(3-({4-[(5-hydroxy-2-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 8.5nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26180BDBM26180(3-({4-[(5-methyl-1H-indazol-4-yl)amino]pyrimidin-2...)
Affinity DataIC50: 12nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26145BDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26186BDBM26186(3-({4-[(5-methyl-1H-indazol-4-yl)amino]pyrimidin-2...)
Affinity DataIC50: 19nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 25191BDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/mole IC50: 59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50142887BDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26185BDBM26185(3-{[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino}b...)
Affinity DataIC50: 33nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 25116BDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26152BDBM26152(3-({4-[(4-hydroxy-2-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26149BDBM26149(3-({4-[(2-bromo-5-hydroxyphenyl)amino]pyrimidin-2-...)
Affinity DataIC50: 41nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26167BDBM26167(3-({4-[(5-methoxy-2-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 54nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26182BDBM26182(3-({4-[(7-methyl-1H-indazol-4-yl)amino]pyrimidin-2...)
Affinity DataIC50: 55nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 25191BDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataIC50: 59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13242BDBM13242(CHEMBL131346 | 2-[(butylcarbamoyl)amino]-4-methyl-...)
Affinity DataIC50: 70nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13242BDBM13242(CHEMBL131346 | 2-[(butylcarbamoyl)amino]-4-methyl-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26147BDBM26147(3-({4-[(3-hydroxy-5-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 73nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50175196BDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataEC50:  78nMAssay Description:Inhibition of TCR stimulated IL2 production in mice administered orallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26156BDBM26156(3-({4-[(5-methoxy-2-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 86nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26151BDBM26151(3-({4-[(2-methylphenyl)amino]pyrimidin-2-yl}amino)...)
Affinity DataIC50: 89nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13241BDBM13241(4-methyl-2-[(phenylcarbamoyl)amino]-N-(2,4,6-trime...)
Affinity DataIC50: 90nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26157BDBM26157(3-({4-[(5-amino-2-methylphenyl)amino]pyrimidin-2-y...)
Affinity DataIC50: 97nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26179BDBM26179(3-{[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino}b...)
Affinity DataIC50: 100nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13244BDBM13244(2-[(benzylcarbamoyl)amino]-4-methyl-N-(2,4,6-trime...)
Affinity DataIC50: 100nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26153BDBM26153(3-({4-[(2-hydroxy-6-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26146BDBM26146(3-({4-[(3-hydroxyphenyl)amino]pyrimidin-2-yl}amino...)
Affinity DataIC50: 130nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50307127BDBM50307127((Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 150nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13240BDBM13240(4-methyl-2-[(methylcarbamoyl)amino]-N-(2,4,6-trime...)
Affinity DataIC50: 170nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13240BDBM13240(4-methyl-2-[(methylcarbamoyl)amino]-N-(2,4,6-trime...)
Affinity DataIC50: 170nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26148BDBM26148(3-({4-[(3-hydroxy-4-methylphenyl)amino]pyrimidin-2...)
Affinity DataIC50: 190nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26154BDBM26154(3-({4-[(5-fluoro-2-methylphenyl)amino]pyrimidin-2-...)
Affinity DataIC50: 270nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13224BDBM13224(CHEMBL130719 | 2-N-benzene-4-methyl-5-N-(2,4,6-tri...)
Affinity DataIC50: 320nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13224BDBM13224(CHEMBL130719 | 2-N-benzene-4-methyl-5-N-(2,4,6-tri...)
Affinity DataIC50: 320nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26168BDBM26168(3-({4-[(2,4-difluorophenyl)amino]pyrimidin-2-yl}am...)
Affinity DataIC50: 350nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26155BDBM26155(3-({4-[(5-chloro-2-methylphenyl)amino]pyrimidin-2-...)
Affinity DataIC50: 380nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50298225BDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US9765037,...)
Affinity DataIC50: 460nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26176BDBM26176(3-{[4-(1H-1,2,3-benzotriazol-7-ylamino)pyrimidin-2...)
Affinity DataIC50: 490nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13223BDBM13223(2-acetamido-4-methyl-N-(2,4,6-trimethylphenyl)-1,3...)
Affinity DataIC50: 510nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26181BDBM26181(3-({4-[(6-methyl-1H-indazol-4-yl)amino]pyrimidin-2...)
Affinity DataIC50: 520nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26175BDBM26175(3-{[4-(quinolin-5-ylamino)pyrimidin-2-yl]amino}ben...)
Affinity DataIC50: 560nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50153835BDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)
Affinity DataIC50: 570nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50229961BDBM50229961(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)
Affinity DataIC50: 660nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13222BDBM13222(CHEMBL128589 | methyl N-{4-methyl-5-[(2,4,6-trimet...)
Affinity DataIC50: 720nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 13222BDBM13222(CHEMBL128589 | methyl N-{4-methyl-5-[(2,4,6-trimet...)
Affinity DataIC50: 720nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50248765BDBM50248765(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)
Affinity DataIC50: 750nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26150BDBM26150(3-[(4-{[5-hydroxy-2-(propan-2-yl)phenyl]amino}pyri...)
Affinity DataIC50: 880nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26165BDBM26165(3-({4-[(2,4-difluorophenyl)amino]pyrimidin-2-yl}am...)
Affinity DataIC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26158BDBM26158(3-({2-[(3-carbamoylphenyl)amino]pyrimidin-4-yl}ami...)
Affinity DataIC50: 1.30E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26177BDBM26177(3-{[4-(1H-indazol-7-ylamino)pyrimidin-2-yl]amino}b...)
Affinity DataIC50: 1.40E+3nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26183BDBM26183(3-({4-[(1-methyl-1H-indazol-4-yl)amino]pyrimidin-2...)
Affinity DataIC50: 1.60E+3nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 26164BDBM26164(3-[(4-{[3-(N-methylacetamido)phenyl]amino}pyrimidi...)
Affinity DataIC50: 1.80E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
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