Compile Data Set for Download or QSAR
Report error Found 239 Enz. Inhib. hit(s) with Target = 'Sonic hedgehog protein'
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443885BDBM50443885(CHEMBL3091556)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443912BDBM50443912(CHEMBL3091466)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443889BDBM50443889(CHEMBL3091552)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443903BDBM50443903(CHEMBL3091565)
Affinity DataIC50: 1nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443896BDBM50443896(CHEMBL3091572)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443920BDBM50443920(CHEMBL3091729)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443902BDBM50443902(CHEMBL3091566)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443892BDBM50443892(CHEMBL3091549)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443921BDBM50443921(CHEMBL3091577)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443913BDBM50443913(CHEMBL3091736)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443894BDBM50443894(CHEMBL3091574)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443891BDBM50443891(CHEMBL3091550)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443887BDBM50443887(CHEMBL3091554)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443893BDBM50443893(CHEMBL3091548)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443890BDBM50443890(CHEMBL3091551)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443897BDBM50443897(CHEMBL3091571)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443915BDBM50443915(CHEMBL3091734)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443900BDBM50443900(CHEMBL3091568)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443905BDBM50443905(CHEMBL3091563)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443917BDBM50443917(CHEMBL3091732)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249185BDBM50249185(4-(4-cyclopropylquinazolin-2-ylamino)-N-(2,6-dimet...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421186BDBM50421186(CHEMBL2086800)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249522BDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249186BDBM50249186(N-(2,6-dimethylphenyl)-4-(4-phenylpyrido[2,3-d]pyr...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401323BDBM50401323(CHEMBL2205230)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401324BDBM50401324(CHEMBL2205229)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401328BDBM50401328(CHEMBL2087239)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401328BDBM50401328(CHEMBL2087239)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401325BDBM50401325(CHEMBL2205228)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421184BDBM50421184(CHEMBL2086798)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443888BDBM50443888(CHEMBL3091553)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50394562BDBM50394562(LDE225 | ERISMODEGIB | N-(6-((2S,6R)-2,6-dimethylm...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401329BDBM50401329(CHEMBL2205225)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249184BDBM50249184(N-(1-methyl-1,2,3,4-tetrahydroquinolin-7-yl)-4-(4-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421190BDBM50421190(CHEMBL2086805)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401326BDBM50401326(CHEMBL2205227)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421187BDBM50421187(CHEMBL2086801)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249522BDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393850BDBM50393850(CHEMBL2160030)
Affinity DataEC50:  7.60nMAssay Description:Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393851BDBM50393851(CHEMBL1221983)
Affinity DataEC50:  8.80nMAssay Description:Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302111BDBM50302111(N-(4-chloro-3-(1-methyl-1H-benzo[d]imidazol-2-yl)p...)
Affinity DataIC50: 9nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421193BDBM50421193(CHEMBL2086802)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443910BDBM50443910(CHEMBL3091558)
Affinity DataIC50: 11nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302139BDBM50302139(N-(3-(1H-benzo[d]imidazol-2-yl)-4-chlorophenyl)-2-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249522BDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 13nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401330BDBM50401330(CHEMBL2205224)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249522BDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443909BDBM50443909(CHEMBL3091559)
Affinity DataIC50: 16nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249488BDBM50249488(4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443916BDBM50443916(CHEMBL3091733)
Affinity DataIC50: 20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
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