Compile Data Set for Download or QSAR
Report error Found 571 Enz. Inhib. hit(s) with Target = 'Sphingosine kinase 2'
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562760BDBM50562760(CHEMBL4750447)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of recombinant human Sphk2 expressed in baculovirus infected Sf9 insect cells using d-erythro-sphingosine as substrate measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562761BDBM50562761(CHEMBL4782021)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant human Sphk2 expressed in baculovirus infected Sf9 insect cells using d-erythro-sphingosine as substrate measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562759BDBM50562759(CHEMBL4783605)
Affinity DataKi:  0.290nMAssay Description:Inhibition of recombinant human Sphk2 expressed in baculovirus infected Sf9 insect cells using d-erythro-sphingosine as substrate measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562758BDBM50562758(CHEMBL4755938)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant human Sphk2 expressed in baculovirus infected Sf9 insect cells using d-erythro-sphingosine as substrate measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562757BDBM50562757(CHEMBL3814580)
Affinity DataKi:  0.980nMAssay Description:Inhibition of recombinant human Sphk2 expressed in baculovirus infected Sf9 insect cells using d-erythro-sphingosine as substrate measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177006BDBM50177006(CHEMBL3814849)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human Sphk2 expressed in baculovirus infected Sf9 insect cells using d-erythro-sphingosine as substrate measured after 20 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237435BDBM50237435(CHEMBL4066270)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237422BDBM50237422(CHEMBL4086094)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628303BDBM50628303(CHEMBL5420859)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237423BDBM50237423(CHEMBL4104017)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of SPHK2 (unknown origin) by FITC-based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628301BDBM50628301(CHEMBL5407736)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628302BDBM50628302(CHEMBL5399307)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50041978BDBM50041978(CHEMBL3134157)
Affinity DataKi:  3.60nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628308BDBM50628308(CHEMBL5405542)
Affinity DataIC50: 11nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523494BDBM50523494(CHEMBL4574678)
Affinity DataIC50: 11nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523494BDBM50523494(CHEMBL4574678)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523495BDBM50523495(CHEMBL4593030)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438167BDBM50438167(CHEMBL2409849)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataIC50: 20nMAssay Description:Inhibition of human SphK2 using sphingosine as substrate incubated for 50 mins by scintillation counting analysis in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523501BDBM50523501(CHEMBL4578165)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523502BDBM50523502(CHEMBL4453199)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514477BDBM50514477(CHEMBL4593983)
Affinity DataEC50:  32nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523506BDBM50523506(CHEMBL4472026)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628314BDBM50628314(CHEMBL5439990)
Affinity DataIC50: 36nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514474BDBM50514474(CHEMBL4462152)
Affinity DataEC50:  37nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438142BDBM50438142(CHEMBL2409847)
Affinity DataIC50: 40nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438161BDBM50438161(CHEMBL2409848)
Affinity DataIC50: 40nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523493BDBM50523493(CHEMBL4551657)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628307BDBM50628307(CHEMBL5433518)
Affinity DataIC50: 42nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628296BDBM50628296(CHEMBL5432322)
Affinity DataIC50: 46nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523498BDBM50523498(CHEMBL4456309)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514475BDBM50514475(CHEMBL4456325)
Affinity DataEC50:  50nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438157BDBM50438157(CHEMBL2409850)
Affinity DataIC50: 50nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523505BDBM50523505(CHEMBL4551903)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514473BDBM50514473(CHEMBL4453931)
Affinity DataEC50:  59nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50546440BDBM50546440(CHEMBL552462)
Affinity DataIC50: 60nMAssay Description:Binding affinity to SphK2 in HEK293 cells assessed as direct target engagement incubated for 24 hrs followed by thermal denaturation at 61 degreeC by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514478BDBM50514478(CHEMBL4570134)
Affinity DataEC50:  73nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514479BDBM50514479(CHEMBL4473353)
Affinity DataEC50:  84nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514473BDBM50514473(CHEMBL4453931)
Affinity DataKi:  89nMAssay Description:Inhibition of recombinant human SphK2 assessed as decrease in [33P]SIP production using sphingosine as substrate in presence of [gamma33P]-ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514473BDBM50514473(CHEMBL4453931)
Affinity DataKi:  89nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]S1P production using varying level of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438165BDBM50438165(CHEMBL2409888)
Affinity DataIC50: 90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438166BDBM50438166(CHEMBL2409867)
Affinity DataIC50: 90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438169BDBM50438169(CHEMBL2409870)
Affinity DataIC50: 90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50266426BDBM50266426(CHEMBL4076808)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human SPHK2 at using sphingosine as substrate after 30 mins in presence of gamma-[32P]-ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50266429BDBM50266429(CHEMBL4074731)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human SPHK2 at using sphingosine as substrate after 30 mins in presence of gamma-[32P]-ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant SphK2 expressed in Sf9 cells assessed as radiolabeled products using 10 uM sphingosine and 10 uM gamma[32P]ATP by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataIC50: 100nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438168BDBM50438168(CHEMBL2409889)
Affinity DataIC50: 110nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523499BDBM50523499(CHEMBL4448423)
Affinity DataIC50: 119nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50523497BDBM50523497(CHEMBL4474024)
Affinity DataIC50: 143nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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