Compile Data Set for Download or QSAR
Report error Found 104 Enz. Inhib. hit(s) with Target = 'cAMP-dependent protein kinase catalytic subunit gamma'
LigandChemical structure of BindingDB Monomer ID 50587771BDBM50587771(CHEMBL5183651)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to PKA (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PKA (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50587770BDBM50587770(CHEMBL5188493)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50228843BDBM50228843(CHEMBL436718)
Affinity DataIC50: 3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 3149BDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50228843BDBM50228843(CHEMBL436718)
Affinity DataKi:  4nMAssay Description:Displacement of ATP from protein kinase A (PKA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 130909BDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibition of Protein Kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human PKAcg using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50242733BDBM50242733(AT-13148)
Affinity DataIC50: 10nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 15211BDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  70nMAssay Description:Binding affinity to human PRKACG incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50505541BDBM50505541(CHEMBL4465866)
Affinity DataKd:  148nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKACG (unknown origin) expressed in baculovirus infected Sf9 insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50505542BDBM50505542(CHEMBL4576489)
Affinity DataKd:  154nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PRKACG (unknown origin) expressed in baculovirus infected Sf9 insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50587769BDBM50587769(CHEMBL5181354)
Affinity DataIC50: 159nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50228839BDBM50228839(CHEMBL415414)
Affinity DataKi:  170nMAssay Description:Displacement of ATP from protein kinase A (PKA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50614310BDBM50614310(CHEMBL5269663)
Affinity DataIC50: 184nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50280450BDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50280450BDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50228839BDBM50228839(CHEMBL415414)
Affinity DataIC50: 300nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  634nMAssay Description:Binding affinity to human PRKACG incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50405349BDBM50405349(CHEMBL5271837)
Affinity DataKi:  740nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50405333BDBM50405333(CHEMBL5270570)
Affinity DataKi:  744nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50506921BDBM50506921(CHEMBL4459800)
Affinity DataIC50: 790nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 412136BDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PKAMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50228846BDBM50228846(CHEMBL265876)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 15211BDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PKA-mediated phosphorylation of kemptide at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228847BDBM50228847(CHEMBL407100)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50228838BDBM50228838(CHEMBL428973)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50358686BDBM50358686(CHEMBL1922138)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50614312BDBM50614312(CHEMBL5284365)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50614314BDBM50614314(CHEMBL5269818)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50299148BDBM50299148(1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo...)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of recombinant PKA (unknown origin) incubated for 60 mins in presence of ATP by electrophoretic caliper fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597471BDBM50597471(CHEMBL5176687)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50228841BDBM50228841(CHEMBL351282)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50011236BDBM50011236(Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 15211BDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of PKA in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50216682BDBM50216682(cid_3542 | 1-(5-Isoquinolinesulfonyl)-2-methylpipe...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of ATP from protein kinase A (PKA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50405348BDBM50405348(CHEMBL5280643)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50026615BDBM50026615(CHEMBL1922045)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50614313BDBM50614313(CHEMBL5283378)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50216682BDBM50216682(cid_3542 | 1-(5-Isoquinolinesulfonyl)-2-methylpipe...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50223628BDBM50223628(CHEMBL1161622)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of protein kinase A expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 14027BDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of human PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 14027BDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 15203BDBM15203(Isoquinoline-5-sulfonic acid piperazin-1 ylamide |...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of cAMP-dependent protein kinase (PKA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2019
Entry Details Article
PubMed
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