TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 8.60nMAssay Description:Displacement of [3H]Pentazocine from guinea pig sigma-1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 49nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 58nMAssay Description:Displacement of [3H]Pentazocine from guinea pig sigma-1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 125nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 216nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 231nMAssay Description:Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 546nMAssay Description:Binding affinity to human histamine 2 receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 578nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 649nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 666nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 696nMAssay Description:Displacement of [3H]DTG from sigma-2 receptor in rat PC12 cells by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 742nMAssay Description:Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 823nMAssay Description:Binding affinity to human histamine 2 receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 840nMAssay Description:Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 883nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 993nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.15E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.18E+3nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.27E+3nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 1.28E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D4 receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 1.63E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.68E+3nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 1.71E+3nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.88E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 2.05E+3nMAssay Description:Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.20E+3nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 2.56E+3nMAssay Description:Displacement of [3H]WIN35428 from human DAT receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 2.77E+3nMAssay Description:Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.24E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 3.36E+3nMAssay Description:Displacement of [3H] NECA from human adrenergic alpha 2A receptor expressed in MDCK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 4.14E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 6.90E+3nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 7.18E+3nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 7.95E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at mouse DOR expressed in CHO cell membranes assessed as inhibition of DPDPE induced [35S]-GTPgammaS binding incubated for 60 min...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mouse DOR expressed in CHO cell membranes assessed as inhibition of DPDPE induced [35S]-GTPgammaS binding incubated for 60 min...More data for this Ligand-Target Pair
Affinity DataIC50: 1.09E+4nMAssay Description:Antagonist activity at mouse MOR expressed in CHO cell membranes assessed as inhibition of DAMGO induced [35S]-GTPgammaS binding incubated for 60 min...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+4nMAssay Description:Antagonist activity at mouse DOR expressed in CHO cell membranes assessed as inhibition of DPDPE induced [35S]-GTPgammaS binding incubated for 60 min...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 83nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 205nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 144nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 85nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 32nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Memorial Sloan Kettering Cancer Center
Curated by ChEMBL
Affinity DataEC50: 163nMAssay Description:Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS bind...More data for this Ligand-Target Pair