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TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50428854(CHEMBL1236924)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma LBD expressed in HEK293 cells by filtration assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466993(CHEMBL4289691)
Affinity DataIC50: <10nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466987(CHEMBL4292343)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12577(Bisphosphonate 2 | CHEMBL997 | JMC515594 Compound ...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466992(CHEMBL4289114)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467002(CHEMBL4284016)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466991(CHEMBL4276720)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25313((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466998(CHEMBL4291888)
Affinity DataIC50:  76nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466997(CHEMBL4284644)
Affinity DataIC50:  87nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467011(CHEMBL4293341)
Affinity DataIC50:  90nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467006(CHEMBL4286904)
Affinity DataIC50:  90nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467004(CHEMBL4288028)
Affinity DataIC50:  94nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466990(CHEMBL4281271)
Affinity DataIC50:  130nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113289(2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467007(CHEMBL4284441)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467003(CHEMBL4290788)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466986(CHEMBL4276733)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12581((3-amino-1-hydroxy-1-phosphonopropyl)phosphonic ac...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466989(CHEMBL4288937)
Affinity DataIC50:  220nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467010(CHEMBL4285419)
Affinity DataIC50:  230nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467008(CHEMBL4281036)
Affinity DataIC50:  230nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466996(CHEMBL4292696)
Affinity DataIC50:  240nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113287(3-[(4,8-dimethyl-nona-3,7-dienyl)-methyl-amino]-pr...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467006(CHEMBL4286904)
Affinity DataIC50:  330nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467009(CHEMBL4284673)
Affinity DataIC50:  330nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467005(CHEMBL4277389)
Affinity DataIC50:  360nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113285(3-[methyl-(4,8,12-trimethyl-trideca-3,7,11-trienyl...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467001(CHEMBL4285780)
Affinity DataIC50:  380nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466987(CHEMBL4292343)
Affinity DataIC50:  460nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466985(CHEMBL4293998)
Affinity DataIC50:  470nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466994(CHEMBL4283486)
Affinity DataIC50:  570nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50460723(CHEMBL4229273)
Affinity DataIC50:  610nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50:  720nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113283(2-[(4-(2-methylpent-2-ene)-pent-3-enyl)(methyl)ami...)
Affinity DataIC50:  740nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467007(CHEMBL4284441)
Affinity DataIC50:  780nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466989(CHEMBL4288937)
Affinity DataIC50:  790nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466995(CHEMBL4285720)
Affinity DataIC50:  800nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25285((1-hydroxy-1-phosphonododecyl)phosphonic acid | CH...)
Affinity DataIC50:  920nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466988(CHEMBL4292527)
Affinity DataIC50:  980nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466986(CHEMBL4276733)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113286((1-Hydroxy-1-phosphono-undecyl)-phosphonic acid | ...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113288((Octylamino-phosphono-methyl)-phosphonic acid | (o...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466999(CHEMBL4294059)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466998(CHEMBL4291888)
Affinity DataIC50:  2.50E+3nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORbeta ligand binding domain expressed in HEK293T cells incubated for 20 hrs by luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467003(CHEMBL4290788)
Affinity DataIC50:  2.60E+3nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50467000(CHEMBL4287249)
Affinity DataIC50:  2.60E+3nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORbeta LBD (71 to 459 residues) expressed in Escherichia coli BL21(DE3) after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50466990(CHEMBL4281271)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [3H]-T0901317 from recombinant human His-SUMO-tagged RORgamma LBD (265 to 518 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  2.93E+3nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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